Synthesis and protein kinase C binding activity of benzolactam-V7

Bioorg Med Chem Lett. 1999 May 17;9(10):1371-4. doi: 10.1016/s0960-894x(99)00207-3.

Abstract

Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCalpha.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzodiazepinones / chemical synthesis*
  • Benzodiazepinones / chemistry
  • Benzodiazepinones / metabolism
  • Binding, Competitive
  • Isoenzymes / metabolism*
  • Models, Molecular
  • Molecular Structure
  • Phorbol 12,13-Dibutyrate / metabolism
  • Protein Binding
  • Protein Kinase C / metabolism*
  • Protein Kinase C-alpha
  • Recombinant Proteins / metabolism

Substances

  • Benzodiazepinones
  • Isoenzymes
  • Recombinant Proteins
  • benzolactam V7
  • Phorbol 12,13-Dibutyrate
  • Protein Kinase C
  • Protein Kinase C-alpha