Abstract
Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCalpha.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzodiazepinones / chemical synthesis*
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Benzodiazepinones / chemistry
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Benzodiazepinones / metabolism
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Binding, Competitive
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Isoenzymes / metabolism*
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Models, Molecular
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Molecular Structure
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Phorbol 12,13-Dibutyrate / metabolism
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Protein Binding
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Protein Kinase C / metabolism*
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Protein Kinase C-alpha
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Recombinant Proteins / metabolism
Substances
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Benzodiazepinones
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Isoenzymes
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Recombinant Proteins
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benzolactam V7
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Phorbol 12,13-Dibutyrate
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Protein Kinase C
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Protein Kinase C-alpha